Iranian nano-vehicle helps cure gastric cancer

November 7, 2014 5:04 am 

TEHRAN, Nov. 6 — Researchers at the Department of Biological Sciences of Tehran’s Kharazmi University have developed a drug-delivery system known as nano-vehicle for treating gastric cancer.

The solubility of Pt(II) complex increased in the presence of β-CN and the optimal nano-vehicle was formed.

The cytotoxicity of free- and encapsulated-Pt(II) complex was evaluated using colorectal carcinoma HCT116 cells, as a cancer model cell line, because platinum drugs have been used mostly for treatment of gastrointestinal cancers.

Results of the study indicated that the cytotoxicity and cellular uptake of the drug was enhanced when entrapped in β-CN nanoparticles.

Polymeric micelles are internalized into the cells via fluid-state endocytosis.

The findings showed that β-CN is an excellent nano-vehicle for targeted delivery of platinum drugs, which are generally recognized as safe and potentially useful in pharmaceutical industries. (PNA/IRNA)



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